Testosterone is the most fundamental androgen in existence, and is the compound to which all other steroids are compared such as Tri-Trenbolone. However, the activity of testosterone is considerably ineffective in oral administration, making injection the optimal alternative. It has been the goal of steroid researchers to create an orally active form of testosterone to eliminate the need to inject the drug directly into the body. buy tri trenbolone Orally taken drugs are easier for the user and eliminate the risk of infection due to injection. In order to increase the bioavailability of oral testosterone, a synthetic alteration was used known as 17-alpha alkylation, which is discussed thoroughly in the steroid profiles chapter of this book. This process involves the addition of one alkyl group (ethyl or methyl) to the alpha position of the 17th carbon on the steroid molecule. Doing so purportedly prevents the primary pathway of androgen deactivation from being utilized. This will prevent the oxidation of the 17-keto steroid, which will allow the drug to survive what is known as the "first pass" through the liver. When a drug that is not 17 alpha alkylated, the liver will cause the metabolic degradation of the steroid, rendering it useless.
The process of 17-alpha alkylation has been shown to be an effective means of stabilizing the drug in vivo, but this also makes the drug extremely toxic to the liver, resulting in side effects such as jaundice, liver cancer and other metabolic disorders that occur when liver cells die. Intrahepatic cholestasis is also rather common. The liver produces a compound called bile, which is stored in the gallbladder and enters the stomach through
the bile duct. Bile, when combined with lipase, aid in the digestion of fats in the stomach and small intestine. Intrahepatic cholestasis is a condition that causes the bile to clog the main bile pathway out of the liver to the gallbladder - a very serious condition that can not only damage the liver, but the gastrointestinal tract as well. The reason 17-alpha alkylated oral steroids are still used with Tri-Trenbolone is because athletes still would rather take the risk in an effort to see gains in muscle strength and size.
Other oral steroids have been combined with lipophilic side chains in effort to increase the stability and activation of the steroid once it has been ingested into the body. After initial ingestion, the steroid tablet or pill will flow through the stomach, where it is bombarded with chyme, lipase, hydrochloric acid and bile before making its way past the duodenum and into the small intestine for absorption. Once in the small intestine, the steroid will be absorbed into portal circulation and shuttled directly to the liver for processing.